Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias (T-ALL), making this receptor a promising target for drugs such as γ-secretase inhibitors, which block a proteolytic cleavage required for NOTCH1 activation. However, the enthusiasm for these therapies has been tempere...

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Detalhes bibliográficos
Main Authors: Palomero, Teresa, Sulis, Maria Luisa, Cortina, Maria, Real, Pedro J., Barnes, Kelly, Ciofani, Maria, Caparros, Esther, Buteau, Jean, Brown, Kristy, Perkins, Sherrie L., Bhagat, Govind, Mishra, Archana, Basso, Giuseppe, Castillo, Mireia, Nagase, Satoru, Cordon-Cardo, Carlos, Parsons, Ramon, Zúñiga-Pflücker, Juan Carlos, Dominguez, Maria, Ferrando, Adolfo A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600418/
https://ncbi.nlm.nih.gov/pubmed/17873882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1636
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