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Computational Analysis of Looping of a Large Family of Highly Bent DNA by LacI

Sequence-dependent intrinsic curvature of DNA influences looping by regulatory proteins such as LacI and NtrC. Curvature can enhance stability and control shape, as observed in LacI loops formed with three designed sequences with operators bracketing an A-tract bend. We explore geometric, topologica...

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主要な著者: Lillian, Todd D., Goyal, Sachin, Kahn, Jason D., Meyhöfer, Edgar, Perkins, N. C.
フォーマット: Artigo
言語:Inglês
出版事項: The Biophysical Society 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2599832/
https://ncbi.nlm.nih.gov/pubmed/18931251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.142471
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