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Computational Analysis of Looping of a Large Family of Highly Bent DNA by LacI

Sequence-dependent intrinsic curvature of DNA influences looping by regulatory proteins such as LacI and NtrC. Curvature can enhance stability and control shape, as observed in LacI loops formed with three designed sequences with operators bracketing an A-tract bend. We explore geometric, topologica...

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Détails bibliographiques
Auteurs principaux: Lillian, Todd D., Goyal, Sachin, Kahn, Jason D., Meyhöfer, Edgar, Perkins, N. C.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2599832/
https://ncbi.nlm.nih.gov/pubmed/18931251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.142471
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