Single-Molecule Spectroscopic Determination of Lac Repressor-DNA Loop Conformation

The Escherichia coli lactose repressor protein (LacI) provides a classic model for understanding protein-induced DNA looping. LacI has a C-terminal four-helix bundle tetramerization domain that may act as a flexible hinge. In previous work, several DNA constructs, each containing two lac operators b...

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Bibliographic Details
Main Authors: Morgan, Michael A., Okamoto, Kenji, Kahn, Jason D., English, Douglas S.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2005
Subjects:
Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366758/
https://ncbi.nlm.nih.gov/pubmed/16085773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.067728
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