Depletion of mitochondrial DNA in leucocytes harbouring the 3243A→G mtDNA mutation

BACKGROUND: The 3243A→G MTTL1 mutation is the most common heteroplasmic mitochondrial DNA (mtDNA) mutation associated with disease. Previous studies have shown that the percentage of mutated mtDNA decreases in blood as patients get older, but the mechanisms behind this remain unclear. OBJECTIVES AND...

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Main Authors: Pyle, Angela, Taylor, Robert W, Durham, Steve E, Deschauer, Marcus, Schaefer, Andrew M, Samuels, David C, Chinnery, Patrick F
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Group 2007
Fag:
Letter to JMG
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597915/
https://ncbi.nlm.nih.gov/pubmed/16950816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2006.043109
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