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Normal Levels of Wild-Type Mitochondrial DNA Maintain Cytochrome c Oxidase Activity for Two Pathogenic Mitochondrial DNA Mutations but Not for m.3243A→G

Mitochondrial DNA (mtDNA) mutations are a common cause of human disease and accumulate as part of normal ageing and in common neurodegenerative disorders. Cells express a biochemical defect only when the proportion of mutated mtDNA exceeds a critical threshold, but it is not clear whether the actual...

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Autori principali: Durham, Steve E. , Samuels, David C. , Cree, Lynsey M. , Chinnery, Patrick F. 
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Human Genetics 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950909/
https://ncbi.nlm.nih.gov/pubmed/17564976
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