Depletion of mitochondrial DNA in leucocytes harbouring the 3243A→G mtDNA mutation

BACKGROUND: The 3243A→G MTTL1 mutation is the most common heteroplasmic mitochondrial DNA (mtDNA) mutation associated with disease. Previous studies have shown that the percentage of mutated mtDNA decreases in blood as patients get older, but the mechanisms behind this remain unclear. OBJECTIVES AND...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pyle, Angela, Taylor, Robert W, Durham, Steve E, Deschauer, Marcus, Schaefer, Andrew M, Samuels, David C, Chinnery, Patrick F
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMJ Group 2007
Pynciau:
Letter to JMG
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597915/
https://ncbi.nlm.nih.gov/pubmed/16950816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2006.043109
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