Tumour selection advantage of non‐dominant negative P53 mutations in homozygotic MDM2‐SNP309 colorectal cancer cells

BACKGROUND: Mdm2 is a natural inhibitor of p53 function and its overexpression impairs p53 transcriptional activity. T→G single‐nucleotide polymorphism at position 309 (SNP309) of mdm2 induces overexpression of mdm2, but inhibits p53. OBJECTIVES: To determine whether SNP309 is a risk‐modifier polymo...

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Autori principali: Alazzouzi, Hafid, Suriano, Gianpaolo, Guerra, Angel, Plaja, Alberto, Espín, Eloi, Armengol, Manel, Alhopuro, Pia, Velho, Sergia, Shinomura, Yasuhisa, González‐Aguilera, Juan José, Yamamoto, Hiroyuki, Aaltonen, Lauri A, Moreno, Víctor, Capellà, Gabriel, Peinado, Miguel Angel, Seruca, Raquel, Arango, Diego
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Group 2007
Soggetti:
Letter to JMG
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597912/
https://ncbi.nlm.nih.gov/pubmed/16825434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2006.042572
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