Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li‐Fraumeni syndrome

Li‐Fraumeni syndrome, resulting from p53 (TP53) germline mutations, represents one of the most devastating genetic predispositions to cancer. Recently, the MDM2 SNP309 (T→G variation) was shown to be associated with accelerated tumour formation in p53 mutation carriers. The impact of the common p53...

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Autors principals: Bougeard, G, Baert‐Desurmont, S, Tournier, I, Vasseur, S, Martin, C, Brugieres, L, Chompret, A, Paillerets, B Bressac‐de, Stoppa‐Lyonnet, D, Bonaiti‐Pellie, C, Frebourg, T
Format: Artigo
Idioma:Inglês
Publicat: BMJ Group 2006
Matèries:
Letter to JMG
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904480/
https://ncbi.nlm.nih.gov/pubmed/16258005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2005.037952
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