Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li‐Fraumeni syndrome

Li‐Fraumeni syndrome, resulting from p53 (TP53) germline mutations, represents one of the most devastating genetic predispositions to cancer. Recently, the MDM2 SNP309 (T→G variation) was shown to be associated with accelerated tumour formation in p53 mutation carriers. The impact of the common p53...

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Hlavní autoři: Bougeard, G, Baert‐Desurmont, S, Tournier, I, Vasseur, S, Martin, C, Brugieres, L, Chompret, A, Paillerets, B Bressac‐de, Stoppa‐Lyonnet, D, Bonaiti‐Pellie, C, Frebourg, T
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Group 2006
Témata:
Letter to JMG
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904480/
https://ncbi.nlm.nih.gov/pubmed/16258005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2005.037952
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