MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid leukemia susceptibility

The p53 tumor suppressor directs the cellular response to many mechanistically distinct DNA-damaging agents and is selected against during the pathogenesis of therapy-related acute myeloid leukemia (t-AML). We hypothesized that constitutional genetic variation in the p53 pathway would affect t-AML r...

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Detalhes bibliográficos
Main Authors: Ellis, Nathan A., Huo, Dezheng, Yildiz, Ozlem, Worrillow, Lisa J., Banerjee, Mekhala, Le Beau, Michelle M., Larson, Richard A., Allan, James M., Onel, Kenan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481552/
https://ncbi.nlm.nih.gov/pubmed/18426989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-126508
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