Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li‐Fraumeni syndrome

Li‐Fraumeni syndrome, resulting from p53 (TP53) germline mutations, represents one of the most devastating genetic predispositions to cancer. Recently, the MDM2 SNP309 (T→G variation) was shown to be associated with accelerated tumour formation in p53 mutation carriers. The impact of the common p53...

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Dettagli Bibliografici
Autori principali: Bougeard, G, Baert‐Desurmont, S, Tournier, I, Vasseur, S, Martin, C, Brugieres, L, Chompret, A, Paillerets, B Bressac‐de, Stoppa‐Lyonnet, D, Bonaiti‐Pellie, C, Frebourg, T
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Group 2006
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Letter to JMG
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904480/
https://ncbi.nlm.nih.gov/pubmed/16258005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2005.037952
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