Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1

Thrombospondin-1 (TSP-1) treatment of dermal microvascular endothelial cells (MvEC) has been shown to upregulate Fas ligand (FasL) and to induce apoptosis by a mechanism that requires caspase-8 activity. We have examined the potential anti-angiogenic effects of TSP-1 on primary human brain MvEC. The...

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Detalhes bibliográficos
Main Authors: Rege, Tanya A., Stewart, Jerry, Dranka, Brian, Benveniste, Etty N., Silverstein, Roy L., Gladson, Candece L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597846/
https://ncbi.nlm.nih.gov/pubmed/18726995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21570
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