Plasminogen Kringle 5 Induces Apoptosis of Brain Microvessel Endothelial Cells: Sensitization by Radiation and Requirement for GRP78 and LRP1

Recombinant plasminogen kringle 5 (rK5) has been shown to induce apoptosis of dermal microvessel endothelial cells (MvEC) in a manner that requires glucose-regulated protein 78 (GRP78). As we are interested in anti-angiogenic therapy for glioblastoma tumors, and the effectiveness of anti-angiogenic...

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Hlavní autoři: McFarland, Braden C., Stewart, Jerry, Hamza, Amal, Nordal, Robert, Davidson, Donald J., Henkin, Jack, Gladson, Candece L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990683/
https://ncbi.nlm.nih.gov/pubmed/19549899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4841
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