Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives

Calcitriol (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-1α,3β,25-triol) is a powerful oncostatic form of vitamin D3 that is of limited clinical utility due to hypercalcemic (toxic) effects. Since the removal of the side chain reduces or eliminates the calcemic activity of vitamin D3, secosteroidal...

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Bibliografske podrobnosti
Main Authors: Zmijewski, Michal A., Li, Wei, Zjawiony, Jordan K., Sweatman, Trevor W., Chen, Jianjun, Miller, Duane D., Slominski, Andrzej T.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597640/
https://ncbi.nlm.nih.gov/pubmed/19037511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b809005j
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