STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease

Graft-versus-host disease (GVHD) is a serious complication of allogeneic bone marrow transplantation, and donor T cells are indispensable for GVHD. Current therapies have limited efficacy, selectivity, and high toxicities. We used a novel flow cytometry technique for the analysis of intracellular ph...

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Hlavní autoři: Lu, Sydney X., Alpdogan, Onder, Lin, Janine, Balderas, Robert, Campos-Gonzalez, Roberto, Wang, Xiao, Gao, Guo-Jian, Suh, David, King, Christopher, Chow, Melanie, Smith, Odette M., Hubbard, Vanessa M., Bautista, Johanne L., Cabrera-Perez, Javier, Zakrzewski, Johannes L., Kochman, Adam A., Chow, Andrew, Altan-Bonnet, Gregoire, van den Brink, Marcel R. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597618/
https://ncbi.nlm.nih.gov/pubmed/18838616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-147322
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