Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses

T-lymphocyte activation displays a remarkable combination of speed, sensitivity, and discrimination in response to peptide–major histocompatibility complex (pMHC) ligand engagement of clonally distributed antigen receptors (T cell receptors or TCRs). Even a few foreign pMHCs on the surface of an ant...

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Bibliographic Details
Main Authors: Altan-Bonnet, Grégoire, Germain, Ronald N
Format: Artigo
Language:Inglês
Published: Public Library of Science 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1262625/
https://ncbi.nlm.nih.gov/pubmed/16231973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0030356
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