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Role of zinc content on the catalytic efficiency of B1 metallo β-lactamases

Metallo β-lactamases (MβL's) are enzymes naturally evolved by bacterial strains under the evolutionary pressure of β-lactam antibiotic clinical use. They have a broad substrate spectrum and are resistant to all the clinically useful inhibitors, representing a potential risk of infection if mass...

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Bibliografische gegevens
Hoofdauteurs: Dal Peraro, Matteo, Vila, Alejandro J., Carloni, Paolo, Klein, Michael L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597527/
https://ncbi.nlm.nih.gov/pubmed/17305336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0657556
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