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Regiospecific Hydration of γ-Hydroxy-α,β-Acetylenic Esters: A Novel Asymmetric Synthesis of Tetronic Acids

[Image: see text] The optically active γ-hydroxy-α,β-acetylenic esters are obtained from the enantioselective reaction of methyl propiolate with both aliphatic and aromatic aldehydes. These compounds can undergo regiospecific hydration in the presence of Zeise’s dimer, [PtCl(2)(C(2)H(4))](2), to gen...

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Detalhes bibliográficos
Main Authors: Rajaram, Amaresh R., Pu, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597458/
https://ncbi.nlm.nih.gov/pubmed/16671771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol060377v
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