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Asymmetric Synthesis of anti-β-Amino-α-Hydroxy Esters via Dynamic Kinetic Resolution of β-Amino-α-Keto Esters

[Image: see text] A method for the asymmetric synthesis of enantioenriched anti-α-hydroxy-β-amino acid derivatives by enantioconvergent reduction of the corresponding racemic α-keto esters is presented. The requisite α-keto esters are prepared via Mannich addition of ethyl diazoacetate to imines fol...

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Autori principali: Goodman, C. Guy, Do, Dung T., Johnson, Jeffrey S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766400/
https://ncbi.nlm.nih.gov/pubmed/23631467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol4009206
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