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Diastereoselective Synthesis of Tetrahydrofurans via Mead Reductive Cyclization of Keto-β-Lactones Derived from the Tandem Mukaiyama Aldol Lactonization (TMAL) Process

The development of a diastereoselective, three-step strategy for the construction of substituted tetrahydrofurans from alkenyl aldehydes based on the tandem Mukaiyama aldol-lactonization process and Mead reductive cyclization of keto β-lactones is reported. Stereochemical outcomes of the TMAL proces...

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Detalhes bibliográficos
Main Authors: Mitchell, T. Andrew, Romo, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597427/
https://ncbi.nlm.nih.gov/pubmed/17973527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo7014246
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