Practical and Highly Enantioselective Synthesis of β-Alkynyl-β-Amino Esters Through Ag-Catalyzed Asymmetric Mannich Reactions of Silylketene Acetals and Alkynyl Imines

[Figure: see text] A readily available iso-leucine-based phosphine ligand is used to promote Ag-catalyzed Mannich reactions between silylketene acetals and various alkynyl imines. Reactions can be effected in the presence of 5 mol % catalyst, without the need for rigorous exclusion of air, and with...

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Hlavní autoři: Josephsohn, Nathan S., Carswell, Emma L., Snapper, Marc L., Hoveyda, Amir H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597397/
https://ncbi.nlm.nih.gov/pubmed/15957928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol050910r
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