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The differentiation of human T(H)-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγT
T helper 17 cells (T(H)-17 cells) are interleukin 17 (IL-17)-secreting CD4(+) T cells involved in autoimmune disease and mucosal immunity. In naive CD4(+) T cells from mice, IL-17 is expressed in response to a combination of IL-6 or IL-21 and transforming growth factor-β (TGF-β) and requires inducti...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597394/ https://ncbi.nlm.nih.gov/pubmed/18454151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1610 |
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