TGF-β-induced Foxp3 inhibits Th17 cell differentiation by antagonizing RORγt function

T helper cells that produce IL-17 (Th17 cells) promote autoimmunity in mice and have been implicated in pathogenesis of human inflammatory diseases. At mucosal surfaces Th17 cells are thought to protect the host from infection while regulatory T (Treg) cells control immune responses and inflammation...

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Detalhes bibliográficos
Main Authors: Zhou, Liang, Lopes, Jared E., Chong, Mark M. W., Ivanov, Ivaylo I., Min, Roy, Victora, Gabriel D., Shen, Yuelei, Du, Jianguang, Rubtsov, Yuri P., Rudensky, Alexander Y., Ziegler, Steven F., Littman, Dan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597437/
https://ncbi.nlm.nih.gov/pubmed/18368049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06878
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