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TGF-β-induced Foxp3 inhibits Th17 cell differentiation by antagonizing RORγt function
T helper cells that produce IL-17 (Th17 cells) promote autoimmunity in mice and have been implicated in pathogenesis of human inflammatory diseases. At mucosal surfaces Th17 cells are thought to protect the host from infection while regulatory T (Treg) cells control immune responses and inflammation...
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Главные авторы: | , , , , , , , , , , , |
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Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
2008
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597437/ https://ncbi.nlm.nih.gov/pubmed/18368049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06878 |
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