5-HT(4)-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles

BACKGROUND AND PURPOSE: The left ventricle in failing hearts becomes sensitive to 5-HT parallelled by appearance of functional G(s)-coupled 5-HT(4) receptors. Here, we have explored the regulatory functions of phosphodiesterases in the 5-HT(4) receptor-mediated functional effects in ventricular musc...

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Detalhes bibliográficos
Main Authors: Afzal, F, Andressen, K W, Mørk, H K, Aronsen, J M, Sjaastad, I, Dahl, C P, Skomedal, T, Levy, F O, Osnes, J-B, Qvigstad, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597261/
https://ncbi.nlm.nih.gov/pubmed/18846035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.339
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