H(2)S-donating sildenafil (ACS6) inhibits superoxide formation and gp91(phox) expression in arterial endothelial cells: role of protein kinases A and G

BACKGROUND AND PURPOSE: Superoxide (O(2)(•−)), derived from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, is associated with acute respiratory distress syndrome (ARDS). NADPH oxidase activity and expression are blocked by nitric oxide (NO) and sildenafil. As another gas, hydrogen sulp...

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Bibliografiset tiedot
Päätekijät: Muzaffar, S, Jeremy, J Y, Sparatore, A, Del Soldato, P, Angelini, G D, Shukla, N
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2008
Aiheet:
Research Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597257/
https://ncbi.nlm.nih.gov/pubmed/18846041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.326
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