H(2)S-donating sildenafil (ACS6) inhibits superoxide formation and gp91(phox) expression in arterial endothelial cells: role of protein kinases A and G

BACKGROUND AND PURPOSE: Superoxide (O(2)(•−)), derived from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, is associated with acute respiratory distress syndrome (ARDS). NADPH oxidase activity and expression are blocked by nitric oxide (NO) and sildenafil. As another gas, hydrogen sulp...

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Main Authors: Muzaffar, S, Jeremy, J Y, Sparatore, A, Del Soldato, P, Angelini, G D, Shukla, N
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597257/
https://ncbi.nlm.nih.gov/pubmed/18846041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.326
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