H(2)S-donating sildenafil (ACS6) inhibits superoxide formation and gp91(phox) expression in arterial endothelial cells: role of protein kinases A and G

BACKGROUND AND PURPOSE: Superoxide (O(2)(•−)), derived from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, is associated with acute respiratory distress syndrome (ARDS). NADPH oxidase activity and expression are blocked by nitric oxide (NO) and sildenafil. As another gas, hydrogen sulp...

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Bibliografiske detaljer
Main Authors: Muzaffar, S, Jeremy, J Y, Sparatore, A, Del Soldato, P, Angelini, G D, Shukla, N
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2008
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597257/
https://ncbi.nlm.nih.gov/pubmed/18846041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.326
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