A human TRIM5α B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus

Human TRIM5α restricts N-tropic murine leukemia virus (N-MLV) but not B-tropic MLV (B-MLV) infection. Here we study B30.2/SPRY domain mutants of human TRIM5α that acquire the ability to inhibit B-MLV infection prior to reverse transcription without losing the ability to restrict N-MLV infection. Rem...

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Detalhes bibliográficos
Main Authors: Diaz-Griffero, Felipe, Perron, Michel, McGee-Estrada, Kathleen, Hanna, Robert, Maillard, Pierre, Trono, Didier, Sodroski, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597210/
https://ncbi.nlm.nih.gov/pubmed/18586294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.05.008
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