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Interplay between the nuclear receptor PXR and the uptake transporter OATP1A2 selectively enhances estrogen effects in breast cancer

The ligand-activated nuclear receptor PXR is known to play a role in the regulated expression of drug metabolizing enzymes and transporters. Recent studies suggest a potential clinically relevant role of PXR in breast cancer. However, the relevant pathway or target genes of PXR in breast cancer biol...

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Detalhes bibliográficos
Main Authors: Meyer zu Schwabedissen, Henriette E., Tirona, Rommel G., Yip, Cindy S., Ho, Richard H., Kim, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597047/
https://ncbi.nlm.nih.gov/pubmed/19010908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0265
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