TNF-α Suppresses Prolyl-4-Hydroxylase α1 Expression via the ASK1–JNK–NonO Pathway

BACKGROUND: Inflammation is known to contribute to the pathogenesis of vascular diseases in which arterial wall extracellular matrix (ECM) homeostasis is disrupted. Tumor necrosis factor-α (TNF-α), a pivotal cytokine that regulates ECM metabolism by increasing degradation and decreasing production o...

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Hlavní autoři: Zhang, Cheng, Zhang, Ming-Xiang, Shen, Ying H., Burks, Jared K., Zhang, Yun, Wang, Jian, LeMaire, Scott A., Yoshimura, Koichi, Aoki, Hiroki, Coselli, Joseph S., Wang, Xing Li
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597036/
https://ncbi.nlm.nih.gov/pubmed/17478756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.107.144881
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