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Increased Hypothalamic Protein Tyrosine Phosphatase 1B Contributes to Leptin Resistance with Age

Animals at advanced ages exhibit a reduction in central leptin sensitivity. However, changes in growth, metabolism, and obesity risk occur much earlier in life, particularly during the transition from youth to middle age. To determine when initial decreases in central leptin sensitivity occur, lepti...

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Detalhes bibliográficos
Main Authors: Morrison, Christopher D., White, Christy L., Wang, Zhong, Lee, Seung-Yub, Lawrence, David S., Cefalu, William T., Zhang, Zhong-Yin, Gettys, Thomas W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596872/
https://ncbi.nlm.nih.gov/pubmed/17038557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2006-0672
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