Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats

Protein tyrosine phosphatase (PTP1B) has been implicated in the negative regulation of insulin and leptin signaling. PTP1B knockout mice are hypersensitive to insulin and leptin and resistant to obesity when fed a high-fat diet. We investigated the role of hypothalamic PTP1B in the regulation of foo...

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Autors principals: Picardi, Paty Karoll, Calegari, Vivian Cristine, de Oliveira Prada, Patrícia, Contin Moraes, Juliana, Araújo, Eliana, Gomes Marcondes, Maria Cristina Cintra, Ueno, Miriam, Carvalheira, José Barreto Campello, Velloso, Licio Augusto, Abdalla Saad, Mario José
Format: Artigo
Idioma:Inglês
Publicat: The Endocrine Society 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2488223/
https://ncbi.nlm.nih.gov/pubmed/18467448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-1506
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