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A Conformational Switch in the Ligand Binding Domain Regulates the Dependence of the Glucocorticoid Receptor on Hsp90: Regulating the Dependence of GR on Hsp90
Steroid hormone receptors (SRs) are transcription factors that act as regulatory switches by altering gene expression in response to ligands. The highly conserved ligand-binding domain (LBD) of SRs is a precise but versatile molecular switch that can adopt distinct conformations. Differential stabil...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596751/ https://ncbi.nlm.nih.gov/pubmed/17367809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.02.057 |
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