A Conformational Switch in the Ligand Binding Domain Regulates the Dependence of the Glucocorticoid Receptor on Hsp90: Regulating the Dependence of GR on Hsp90

Steroid hormone receptors (SRs) are transcription factors that act as regulatory switches by altering gene expression in response to ligands. The highly conserved ligand-binding domain (LBD) of SRs is a precise but versatile molecular switch that can adopt distinct conformations. Differential stabil...

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Bibliografiset tiedot
Päätekijät: Ricketson, D., Hostick, U., Fang, L., Yamamoto, K.R., Darimont, B.D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2007
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596751/
https://ncbi.nlm.nih.gov/pubmed/17367809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.02.057
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