Role of prostaglandin D(2) receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo

Although COX-dependent production of prostaglandins (PGs) is known to be crucial for tumor angiogenesis and growth, the role of PGD(2) remains virtually unknown. Here we show that PGD(2) receptor (DP) deficiency enhances tumor progression accompanied by abnormal vascular expansion. In tumors, angiog...

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Detalhes bibliográficos
Main Authors: Murata, Takahisa, Lin, Michelle I., Aritake, Kosuke, Matsumoto, Shigeko, Narumiya, Shu, Ozaki, Hiroshi, Urade, Yoshihiro, Hori, Masatoshi, Sessa, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596745/
https://ncbi.nlm.nih.gov/pubmed/19060214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805171105
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