Runx2 Transcriptional Activation of Indian Hedgehog and a Downstream Bone Metastatic Pathway in Breast Cancer Cells

Runx2, required for bone formation, is ectopically expressed in breast cancer cells. To address the mechanism by which Runx2 contributes to the osteolytic disease induced by MDA-MB-231 cells, we investigated the effect of Runx2 on key components of the “vicious cycle” of TGFβ mediated tumor growth a...

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Bibliographic Details
Main Authors: Pratap, Jitesh, Wixted, John J., Gaur, Tripti, Zaidi, Sayyed K., Dobson, Jason, Veeraraj, Karthiga Devi, Hussain, Sadiq, van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596479/
https://ncbi.nlm.nih.gov/pubmed/18829534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1078
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