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A Catalytic Role of Heparin within the Extracellular Matrix

We investigated the mechanism by which heparin enhances the binding of vascular endothelial growth factor (VEGF) to the extracellular matrix protein fibronectin. In contrast to other systems, where heparin acts as a protein scaffold, we found that heparin functions catalytically to modulate VEGF bin...

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Détails bibliographiques
Auteurs principaux: Mitsi, Maria, Forsten-Williams, Kimberly, Gopalakrishnan, Manoj, Nugent, Matthew A.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596404/
https://ncbi.nlm.nih.gov/pubmed/18845539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806692200
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