A Catalytic Role of Heparin within the Extracellular Matrix

We investigated the mechanism by which heparin enhances the binding of vascular endothelial growth factor (VEGF) to the extracellular matrix protein fibronectin. In contrast to other systems, where heparin acts as a protein scaffold, we found that heparin functions catalytically to modulate VEGF bin...

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Bibliographic Details
Main Authors: Mitsi, Maria, Forsten-Williams, Kimberly, Gopalakrishnan, Manoj, Nugent, Matthew A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596404/
https://ncbi.nlm.nih.gov/pubmed/18845539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806692200
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