Transglutaminase-2 Interaction with Heparin: IDENTIFICATION OF A HEPARIN BINDING SITE THAT REGULATES CELL ADHESION TO FIBRONECTIN-TRANSGLUTAMINASE-2 MATRIX

Heparan sulfate proteoglycans are critical binding partners for extracellular tranglutaminase-2 (TG2), a multifunctional protein involved in tissue remodeling events related to organ fibrosis and cancer progression. We previously showed that TG2 has a strong affinity for heparan sulfate (HS)/heparin...

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Main Authors: Lortat-Jacob, Hugues, Burhan, Izhar, Scarpellini, Alessandra, Thomas, Aline, Imberty, Anne, Vivès, Romain R., Johnson, Timothy, Gutierrez, Aldo, Verderio, Elisabetta A. M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Glycobiology and Extracellular Matrices
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365763/
https://ncbi.nlm.nih.gov/pubmed/22442151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337089
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