Active Cystathionine β-Synthase Can Be Expressed in Heme-free Systems in the Presence of Metal-substituted Porphyrins or a Chemical Chaperone

Cystathionine β-synthase (CBS), a key enzyme in the metabolism of homocysteine, has previously been shown to require a heme co-factor for maximal activity. However, the biochemical function of the CBS heme is not well defined. Here, we show that expression of human CBS in heme-deficient strains of S...

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Bibliographic Details
Main Authors: Majtan, Tomas, Singh, Laishram R., Wang, Liqun, Kruger, Warren D., Kraus, Jan P.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596375/
https://ncbi.nlm.nih.gov/pubmed/18849566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805928200
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