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Botulinum Neurotoxin Devoid of Receptor Binding Domain Translocates Active Protease
Clostridium botulinum neurotoxin (BoNT) causes flaccid paralysis by disabling synaptic exocytosis. Intoxication requires the tri-modular protein to undergo conformational changes in response to pH and redox gradients across endosomes, leading to the formation of a protein-conducting channel. The ∼50...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596314/ https://ncbi.nlm.nih.gov/pubmed/19096517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000245 |
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