Bi-Directional Heterologous Desensitization Between the Major HIV-1 Co-Receptor CXCR4 and the κ-Opioid Receptor

We previously characterized multiple interactions between chemokine and opioid G-protein coupled receptors (GPCR), and we found both µ and δ-opioid receptors cross-desensitize CCR1, CCR2, CCR5, but not CXCR4. Here we report that the κ-opioid receptor (KOR) is able to cross-desensitize CXCR4, and thi...

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Main Authors: Finley, Matthew J., Chen, Xiaohong, Bardi, Guiseppe, Davey, Penny, Geller, Ellen B., Zhang, Lily, Adler, Martin W., Rogers, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596309/
https://ncbi.nlm.nih.gov/pubmed/18533278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2008.04.021
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