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Transcriptional regulation of the major HIV-1 coreceptor, CXCR4, by the κ opioid receptor

Previous studies have demonstrated that KOR activation results in decreased susceptibility to infection by HIV-1 in human PBMCs. In the present studies, we have found this effect is, in part, a result of down-regulation of the major HIV-1 coreceptor, CXCR4. Using a combination of biochemical approac...

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Autores principales: Finley, Matthew J., Steele, Amber, Cornwell, William D., Rogers, Thomas J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Leukocyte Biology 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114596/
https://ncbi.nlm.nih.gov/pubmed/21447649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1010546
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