Structure of the wild-type human BCL6 POZ domain

BCL6 is a transcriptional repressor that is overexpressed in diffuse large B-cell lymphoma and follicular lymphoma. The N-terminal POZ domain of BCL6 interacts with transcriptional corepressors and targeting these associations is a promising therapeutic strategy. Previous structural studies of the B...

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Bibliografiske detaljer
Main Authors: Stead, Mark A., Rosbrook, Gareth O., Hadden, Jonathan M., Trinh, Chi H., Carr, Stephen B., Wright, Stephanie C.
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2008
Fag:
Protein Structure Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593701/
https://ncbi.nlm.nih.gov/pubmed/19052359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309108036063
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