The Ansamycin Antibiotic, Rifamycin SV, Inhibits BCL6 Transcriptional Repression and Forms a Complex with the BCL6-BTB/POZ Domain

BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ∼40% of diffuse large B-cell lymphoma. BCL6 interacts with co-repressor, SMRT, and this is essential for its role in lymphomas. Peptide or small molecule inhibitors, which prevent...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Evans, Sian E., Goult, Benjamin T., Fairall, Louise, Jamieson, Andrew G., Ko Ferrigno, Paul, Ford, Robert, Schwabe, John W. R., Wagner, Simon D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942486/
https://ncbi.nlm.nih.gov/pubmed/24595451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090889
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker