Genotoxic Stress-Induced Cyclin D1 Phosphorylation and Proteolysis Are Required for Genomic Stability

While mitogenic induction of cyclin D1 contributes to cell cycle progression, ubiquitin-mediated proteolysis buffers this accumulation and prevents aberrant proliferation. Because the failure to degrade cyclin D1 during S-phase triggers DNA rereplication, we have investigated cellular regulation of...

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Bibliographic Details
Main Authors: Pontano, Laura L., Aggarwal, Priya, Barbash, Olena, Brown, Eric J., Bassing, Craig H., Diehl, J. Alan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593367/
https://ncbi.nlm.nih.gov/pubmed/18809569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01085-08
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