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Substance P Stimulates Cyclooxygenase-2 and Prostaglandin E(2) Expression through JAK-STAT Activation in Human Colonic Epithelial Cells
Substance P (SP) via its neurokinin-1 receptor (NK-1R) regulates several gastrointestinal functions. We previously reported that NK-1R-mediated chloride secretion in the colon involves formation of PG. PGE(2) biosynthesis is controlled by cyclooxygenase-1 (COX-1) and COX-2, whose induction involves...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593099/ https://ncbi.nlm.nih.gov/pubmed/16585602 |
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