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Substance P mediates antiapoptotic responses in human colonocytes by Akt activation

We examined the hypothesis that substance P (SP) and the neurokinin-1 receptor (NK-1R), both in vitro and in vivo, promote mucosal healing during recovery from colitis by stimulating antiapoptotic pathways in human colonic epithelial cells. For the in vitro experiments, human nontransformed NCM460 c...

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Detalhes bibliográficos
Main Authors: Koon, Hon-Wai, Zhao, Dezheng, Zhan, Yanai, Moyer, Mary P., Pothoulakis, Charalabos
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794289/
https://ncbi.nlm.nih.gov/pubmed/17264209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610664104
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