Substance P mediates antiapoptotic responses in human colonocytes by Akt activation

We examined the hypothesis that substance P (SP) and the neurokinin-1 receptor (NK-1R), both in vitro and in vivo, promote mucosal healing during recovery from colitis by stimulating antiapoptotic pathways in human colonic epithelial cells. For the in vitro experiments, human nontransformed NCM460 c...

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Bibliographic Details
Main Authors: Koon, Hon-Wai, Zhao, Dezheng, Zhan, Yanai, Moyer, Mary P., Pothoulakis, Charalabos
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794289/
https://ncbi.nlm.nih.gov/pubmed/17264209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610664104
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