Viral and host factors induce macrophage activation and loss of Toll Like Receptor tolerance in chronic HCV infection

BACKGROUND&AIMS: Persistent inflammation contributes to progression of liver damage in chronic HCV (cHCV) infection. Repeated exposure to Toll like receptor (TLR) ligands results in tolerance, a protective mechanism aimed at limiting inflammation. METHODS: Monocytes/macrophages were repeatedly s...

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Main Authors: Dolganiuc, Angela, Norkina, Oxana, Kodys, Karen, Catalano, Donna, Bakis, Gennadiy, Marshall, Christopher, Mandrekar, Pranoti, Szabo, Gyongyi
Format: Artigo
Language:Inglês
Published: 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593079/
https://ncbi.nlm.nih.gov/pubmed/17916356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2007.08.003
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