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Requirement for binding multiple ATPs to convert a GroEL ring to the folding-active state

Production of the folding-active state of a GroEL ring involves initial cooperative binding of ATP, recruiting GroES, followed by large rigid body movements that are associated with ejection of bound substrate protein into the encapsulated hydrophilic chamber where folding commences. Here, we have a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chapman, Eli, Farr, George W., Fenton, Wayne A., Johnson, Steven M., Horwich, Arthur L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592988/
https://ncbi.nlm.nih.gov/pubmed/19050077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810657105
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