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Requirement for binding multiple ATPs to convert a GroEL ring to the folding-active state

Production of the folding-active state of a GroEL ring involves initial cooperative binding of ATP, recruiting GroES, followed by large rigid body movements that are associated with ejection of bound substrate protein into the encapsulated hydrophilic chamber where folding commences. Here, we have a...

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Detalhes bibliográficos
Main Authors: Chapman, Eli, Farr, George W., Fenton, Wayne A., Johnson, Steven M., Horwich, Arthur L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592988/
https://ncbi.nlm.nih.gov/pubmed/19050077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810657105
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