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Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase

Smoothened, a heptahelical membrane protein, functions as the transducer of Hedgehog signaling. The kinases that modulate Smoothened have been thoroughly analyzed in flies. However, little is known about how phosphorylation affects Smoothened in vertebrates, mainly, because the residues, where Smoot...

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Detalhes bibliográficos
Main Authors: Philipp, Melanie, Fralish, Gregory B., Meloni, Alison R., Chen, Wei, MacInnes, Alyson W., Barak, Lawrence S., Caron, Marc G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592680/
https://ncbi.nlm.nih.gov/pubmed/18815277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-05-0448
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