Characterization of the steric defense of the HIV-1 gp41 N-trimer region

During viral entry, HIV gp41 adopts a transient conformation called the “prehairpin intermediate” in which a highly conserved therapeutic target, the N-trimer, is exposed. Despite extensive discovery efforts, potent and broadly neutralizing antibodies that target the N-trimer are elusive. We previou...

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Bibliographic Details
Main Authors: Eckert, Debra M., Shi, Yu, Kim, Sunghwan, Welch, Brett D., Kang, Eunchai, Poff, Emily S., Kay, Michael S.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590922/
https://ncbi.nlm.nih.gov/pubmed/18802030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.038273.108
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